Research from our Eur-ush consortium is presented around the world by Dr. Ieva Sliesoraityte
-Sliesoraityte I, Sahel JA. Eur-USH database: European wide genotype and phenotype related database for Usher syndrome. International scientific meeting of ERA-NET E-Rare-2, 20-21 January 2014, Athens, Greece (Poster presentation).
-Sliesoraityte I. Restoring vision: today and tomorrow. TedxVilnius, 22 February 2014, Vilnius, Lithuania (Plenary oral presentation).
-Sliesoraityte I. Vision Restoration Potential in Blind Humans. COINS, 3 -8 March, 2014, Vilnius, Lithuania (Plenary oral presentation).
-Sliesoraityte I, Mohand-Saïd S, Dagostinoz D, Kotliar K, Miloudi S, Sahel JA. Cones structure and function related patterns in Usher syndrome patients. ARVO, 4-8 May 2014, Orlando, Florida, USA (Poster presentation).
-Dagostinoz D, Sliesoraityte I, Mohand-Saïd S, Audo I, Sahel JA. Central retina morphology in patients with genetically confirmed Usher syndrome. ARVO, 4-8 May 2014, Orlando, Florida, USA (Poster presentation).
-Mohand-Saïd S,Sliesoraityte I, Dagostinoz D, Audo I, Pâques M, Sahel JA. Retina specific patterns in genetically confirmed Usher type III patients. ARVO, 4-8 May 2014, Orlando, Florida, USA (Poster presentation).
-Kotliar K, Schmaderer C, Tholen T, Schmidt-Trucksaess A, Lanzl I, Sliesoraityte I, Heemann U, Baumann B. Dynamic retinal vessel reaction to flickering light is changed in chronic hemodialysis patients. ARVO, 4-8 May 2014, Orlando, Florida, USA (Poster presentation).
-Ehrlich AC, Nguyen MD, Raza AS, Sliesoraityte I, Mast A, Schiefer U, Hood DC. Testing a Model of Glaucomatous Damage of the Macula and Assessing the Placement of Visual Field Test Points Using High-Density Perimetry. ARVO, 4-8 May 2014, Orlando, Florida, USA (Poster presentation).
-Hood DC, Nguyen M, Ehrlich AC, Raza AS, Sliesoraityte I, De Moraes CG, Ritch R, Schiefer U. A Test of a Model of Glaucomatous Damage of the Macula With High-Density Perimetry: Implications for the Locations of Visual Field Test Points. Transl Vis Sci Technol. 2014 Jun 19;3(3):5.
-Sliesoraityte I. EURUSH – importance of phenotype and genotype related database in development treatment potentials for USHER syndrome patients. Retina International, June 27-28, 2014, Paris, France (Oral presentation).
-Sliesoraityte I, Mohand-Said S, Tunde P, Sahel JA. The prevalence and severity of cystic macula lesions in genetically confirmed Usher syndrome patients. International. Symposium on Usher Syndrome, July 10-12, 2014, Boston, Massachusetts, USA (Poster presentation).
-Sliesoraityte I, Machin C, Makowiecka K, Mohand-Said S, Sahel JA. Chromatic pupillometry for assessment functional rod and cone patterns in Usher syndrome patients. EVER 2014, Nice October 1-4, 2014, Nice, France (Oral presentation).
-Sliesoraityte I. EurUSH: genotype and phenotype related database. XXXIII Annual retina Meeting, 08- 11 October, 2014, Guadalajara, Mexico (Oral presentation, Invited speaker).
-Sliesoraityte I. Adaptive optics and OCT imaging in inherited retinal degenerations. XXXIII Annual retina Meeting, 08- 11 October, 2014, Guadalajara, Mexico (Oral presentation, Invited speaker).
Dr. Ieva SLIESORAITYTE (INSERM, CIC 1243, Institute de la Vision, 75012 Paris, Paris) received the prestigious EVER 2014 Alta Eficacia award
Different articles write about our Usher research
Dr. Ieva Sliesoraityte is mentioned is different articles online laterly, all are accessible via the weblinks below:
Article in International Innovation
Dr. Erwin van Wijk of the Radboudumc (Nijmegen, Netherlands) recently featured in the global dissemination publication; International Innovation. You can view the article here (page 13-15).
Publications with E-RARE so far:
Nagel-Wolfrum et al., 2014 Vis. Neuroscience 31:309-316
Nagel-Wolfrum et al., 2014 Adv Exp Med Biol. 801: 741 – 747
Karstetter et al., 2015 Hum Mol Genet. 24:972-986
Annual meeting EUR-USH 2014 in Mainz, 25th and 26th of September
Press release of the Eur-Ush Kick-off meeting in Nijmegen (The Netherlands)
European young investigators network for Usher syndrome awarded an E-Rare collaborative research project for young scientists
EU project for research on rare Usher syndrome
(Mainz. 13 November 2013, lei) Based on a ranking list that was established by the EU Scientific Evaluation Committee, the E-Rare funding bodies recommended the European young investigators network for Usher syndrome (EUR-USH) coordinated by Dr. Kerstin Nagel-Wolfrum from Johannes Gutenberg University Mainz for funding. Out of 82 submitted projects, EUR-USH was among the 11 excellent scientific projects that were chosen after a competitive two-step scientific evaluation by peers. In October 2013, researchers held their kick-off meeting in Nijmegen, the Netherlands.
In addition to Johannes Gutenberg Mainz University, Germany, five other research institutions, namely AIBILI and IBILI in Coimbra, Portugal, INSERM institutes in Paris and Montpellier, France, and the Radboud UMC in Nijmegen, the Netherlands, will participate in the EUR-USH collaborative project. Financial support for the project will be provided by the national funding agencies, the German Federal Ministry of Education and Research (BMBF), the Portuguese Foundation for Science and Technology (FCT), the French National Research Agency (ANR), and the Netherlands Organisation for Health Research and Development (ZonMW).
In the EUR-USH network, young investigators with different backgrounds in science, clinical medicine, and genetic diagnostics synergize their expertise to shed more light upon the rare genetic disease Usher syndrome (USH). USH is the most common form of hereditary combined deaf-blindness in man. Since USH is genetically and clinically heterogeneous, diagnosing this disease is very challenging. So far the pathomechanisms resulting in the blindness of Usher patients are not fully understood. While the loss of hearing can currently be compensated by the use of cochlear implants, there is still no treatment for the associated blindness.
The EUR-USH project is divided into three components. The first component involves two Portuguese and two French work groups. Among their tasks are the improvement of Usher clinical diagnosis and the elaboration of significant markers for Usher disease progression. Results of the study will be uploaded into the newly established EUR-USH database. In the second segment, work groups in the Netherlands and Germany will concentrate on identifying the molecular pathogenesis of Usher syndrome. By applying proteomic and imaging approaches they aim to identify novel members of the USH interactome to unravel common cellular pathways in which USH proteins are involved and provide candidates or modifier genes for USH and related retinal degenerations. In the third segment, groups will be developing treatment methods for the ophthalmologic component of the disease. They will evaluate two different approaches, gene augmentation and translational read-though, to treat the progressive retinal degeneration of Usher syndrome patients.
The scientists hope that the interdisciplinary collaboration will help further understanding of the clinical, genetic, and molecular background of Usher syndrome and will provide a valuable contribution to possible treatment approaches. The primary objective of the European research team is to improve the quality of life for Usher patients.
Dr. Kerstin Nagel-Wolfrum (EUR-USH Coordinator)
Cell and Matrix Biology
Institute of Zoology
Johannes Gutenberg University Mainz (JGU)
D 55099 Mainz, GERMANY
phone +49 6131 39-20131 / 39-23934
fax +49 6131 39-23815
European Research Projects on Rare Diseases driven by Young Investigators